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<title>Haaze.com / chrmartsmh / All</title>
<link>http://www.haaze.com</link>
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<pubDate>Tue, 19 Apr 2011 07:11:05 +0000</pubDate>
<language>en</language>
<item>
<title><![CDATA[New imaging technique could personalize cancer therapy]]></title>
<link>http://www.haaze.com/story.php?title=new-imaging-technique-could-personalize-cancer-therapy</link>
<comments>http://www.haaze.com/story.php?title=new-imaging-technique-could-personalize-cancer-therapy</comments>
<pubDate>Tue, 19 Apr 2011 07:11:05 +0000</pubDate>
<dc:creator>chrmartsmh</dc:creator>
<category>Social</category>
<guid>http://www.haaze.com/story.php?title=new-imaging-technique-could-personalize-cancer-therapy</guid>
<description><![CDATA[Susannah Gal (left) and Susan Bane have devised a new imaging technique to view specific proteins in action.(Credit:Jonathan Cohen)Two professors at Binghamton University in New York are using a novel imaging technique to observe the behavior of an enzyme--called tubulin tyrosine ligase, or TTL--as its behavior can suggest whether certain cancer cells might grow more aggressively than others.Though they are not developing actual therapies, Susan Bane and Susannah Gal say their research could help further personalize targeted cancer therapies.&quot;Potentially, we could put [a tumor sample] in our labeling system and say, 'Yes, that has a problem with the TTL system, and therefore you should be more aggressive with it,'&quot; says Gal, whose work is funded by the National Institute of General Medical Sciences. &quot;Or we could say, 'That's probably OK, so you can treat it with normal chemotherapy.'&quot;The enzyme TTL involves microtubules, which both help chromosomes line up correctly during cell division and provide part of the scaffolding of a cell's structure. Those microtubules are made of proteins called tubulin' the enzyme carboxypeptidase clips an amino acid called tyrosine off the ends of some of these proteins, and later the enzyme TTL puts that tyrosine back on.Bane says it's unclear why tyrosine is clipped off only to be reattached, but it's clearly an important part of the cell's cycle: &quot;We do know that if you don't have that enzyme, you'll die.&quot;In some cancer cells, that cycle of removing and reattaching tyrosine is disrupted, with too many tubulins lacking tyrosine altogether. Tumors made of those cells, Bane says, &quot;tend to grow more aggressively.&quot;Berkeley Lab published the first 3D model of tubulin in 1998.(Credit:Berkeley Lab)Being able to watch this cycle, then, could provide profound insights into the nature of a particular person's cancer and how to treat it. But watching these microtubules divide is tricky' most fluorescent markers don't distinguish between tubulin and other protein molecules and will bond to any of them. Typically, markers that can distinguish between them are so big that they block the view of the protein being studied.This is where their new imaging technique comes into play. To mark only tubulin, Bane and Gal dressed it in a &quot;hat&quot;--a special derivative of tyrosine that Bane created for the project--and then introduced a fluorescent molecule that lights up only when it bonds with that special tyrosine, allowing researchers to distinguish tubulin from other objects in the cell and watch how it behaves.In 1998, after 30 years of work, scientists completed 3D imaging of the atomic structure of tubulin. Today, Bane and Gal hope that being able to watch tubulin in action might will provide significant insights into how to treat an individual's specific tumor more effectively.<br/><br/>0 Vote(s) ]]></description>
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<title><![CDATA[Maker of driving app miffed at RIM's takedown]]></title>
<link>http://www.haaze.com/story.php?title=maker-of-driving-app-miffed-at-rims-takedown</link>
<comments>http://www.haaze.com/story.php?title=maker-of-driving-app-miffed-at-rims-takedown</comments>
<pubDate>Wed, 30 Mar 2011 07:10:42 +0000</pubDate>
<dc:creator>chrmartsmh</dc:creator>
<category>Technology</category>
<guid>http://www.haaze.com/story.php?title=maker-of-driving-app-miffed-at-rims-takedown</guid>
<description><![CDATA[PhantomAlert&amp;39's app running on a GPS system, where it remains available.(Credit:CNET)The maker of a controversial mobile app that critics contend helps drunken drivers avoid police says his company is getting a raw deal from politicians and app marketplaces.Up until last week, driving-alerts application PhantomAlert had been available on Research In Motion's BlackBerry App World. PhantomAlert CEO Joe Scott is miffed that the software has been taken down by RIM, in a decision that was not shared with him. &quot;It's just sad, we never got contacted by the senators or anyone else,&quot; Scott said in an interview with CNET this morning. &quot;We're more than just DUI checkpoints. We do school zones, speed bumps, and we're endorsed by over 35 police departments.&quot; PhantomAlert's takedown follows a letter published last week by a group of U.S. senators urging Apple, Google, and RIM to remove applications they said encouraged drunken driving by supplying users with information about DUI checkpoints.The initial letter, which was drafted by Sens. Charles Schumer (D-N.Y.), Harry Reid (D-Nev.), Frank Lautenberg (D-N.J.), and Tom Udall (D-N.M.), urged the three technology companies to self-police their mobile application stores, removing applications that contained things like a database of driving under the influence (DUI) checkpoints, and real-time alerts of their presence to app users. So far, only RIM has complied with the request, pulling down an unspecified number of applications that met these criteria including PhantomAlert as well as crowd-sourced speed-trap finder Trapster. CNET reached out to RIM for comment on how many apps were a part of that sweep and if any have been given a reprieve, but the company declined to comment.Meanwhile, Apple has not addressed the original letter, and Google told CNET last week that the description of what these apps do did not violate its Android Marketplace policies. CNET's congressional sources say the senators have not provided an exhaustive list of apps to the three companies, but have cited examples and asked the companies to search their database of applications and remove those that are of the type described.Since PhantomAlert's removal, Scott says he's been in contact with RIM, though the company has been unwilling to bring it back on the market. Scott said he worries what kind of precedent this sets for the group to go after other tools that surface such information.&quot;What's scary about this is if people start tweeting about (police checkpoints). Are they going to go after Twitter, are they going to go after Facebook I don't think that's the right approach.&quot; Don't feel too bad though. Scott says the exposure from this has boosted downloads of the application on other platforms by as much as 8,000 percent and paid subscriptions by around 3,000 percent, including in Google's and Apple's mobile marketplaces, as well as on various GPS devices where it can be installed. A similar effect has hit other application makers that provide information on police checkpoints alongside other traffic-related information. Fuzz Alert, which also serves up the location of DUI checkpoints, has remained safe since Apple has not taken action to remove such applications.(Credit:Fuzz Alert)One of those is Fuzz Alert, which remains exclusive to Apple's App Store. Owner Steve Croke, who CNET spoke with, said that his application has seen a dramatic surge in popularity, trending near the top of the navigation category in the App Store following the attention. Even so, Croke said that DUI checkpoints play an incredibly small part in his application's features and data sourcing.&quot;Less than 5 percent of the traps in my system are DUI checkpoints,&quot; Croke said. Instead, the application aims to alert users to intersections with red-light and speed cameras by sending out audio notifications when in range of known locations. Croke also said that the DUI checkpoint feature was not the reason he made the app in the first place.&quot;Never was the intent to make someone screw with the DUI checkpoints. It's basically alerting people that the smart thing is to not drink and drive, and being in this space I see all the bad things about it,&quot; Croke said. &quot;If I can keep one guy from not putting a key to the ignition, I think I've had a big win.&quot;Croke said the inspiration for the app stemmed from him getting a speeding ticket on a stretch of road that had a photo radar device near his house. That particular time he wasn't paying attention and blew right past it. &quot;It just dawned on me that this is the perfect app to alert someone to be aware of where you are,&quot; Croke said. Croke also believes himself to be lucky that he didn't spend the time or the effort developing his application on RIM's platform, and says the company's actions are a big turnoff to him. &quot;My first reaction was 'Wow, I'm glad I didn't develop for that platform,'&quot; Croke said. &quot;That would crush a business.&quot;Siding with app makers like Croke and Scott is the Association for Competitive Technology (ACT), an advocacy group for small businesses. Following the original letter, ACT said that the senators had missed the point.&quot;The suggestion that the government should compel Apple, RIM, or other mobile application stores to block programs that simply allow users to report information based on location is misguided at best,&quot; said Morgan Reed, ACT's executive director, in a statement last week. &quot;Taken to its conclusion, that would require blocking apps like Foursquare and Loopt.&quot;In a follow-up letter addressed to Schumer and published earlier this week, ACT President Jonathan Zuck noted that the data being used in apps like PhantomAlert is being furnished by law enforcement agencies:&quot;I understand from your letter and further press activity that you consider apps like PhantomAlert and Trapster to be in conflict with the public interest on the issue of traffic safety. I respectfully suggest that you may have been unaware that law enforcement agencies are legally required to publish data featured in these programs. Moreover, they believe the widespread dissemination of this information effectively serves to reduce speeding and improve traffic safety.&quot;Zuck went on to say that the mobile app industry is growing, and that most developers are in America, which means that cutting apps could send jobs overseas. &quot;If the mobile application storefronts begin to pull apps outside of the regular regulatory environment or terms of service agreements simply to respond to any extra-governmental missive, we fear it will harm growth here, but more importantly lead to aggressive action abroad where other governments may see such action as a tool to curb U.S. competitiveness.&quot;Not everyone is siding with the app makers though. Delaware Attorney General Beau Biden, son of Vice President Joe Biden, and Maryland Attorney General Doug Gansler sent a letter to Apple and Google earlier this week. In it, the pair urged the companies to flat out ban such apps, referring to them as &quot;nothing more than an overt method of circumventing laws that were specifically enacted to save lives,&quot; and a &quot;'how-to' guide to evade DUI checkpoints and endanger the lives of innocent citizens on our roads.&quot; That approach has been met with similar responses from the two companies: Apple not issuing a public response, and Google once again saying that the claim had not provided specific examples.Mobile application marketplaces continue to face censorship issues, and are a point of competition among the companies that create and control them. Each of the three companies has its own policies on what is and is not allowed, but all bar anything illegal or that encourages illegal behavior. Though the gray area with these applications in particular has further demonstrated that there is a subtle difference in approach. While Apple has so far been seen as the most conservative of the bunch, keeping out some applications that competitors like Google have allowed for sale, it now sits in the same camp as the search giant, while RIM has gone in a different direction. As Fuzz Alert's Croke noted, this could change a developer's inclination to put in the sometimes considerable resources necessary to get an application developed and published. That doesn't mean Apple's and Google's application stores are safe havens for applications like these. As the two companies spell out in their storefront guidelines, things change.<br/><br/>0 Vote(s) ]]></description>
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<title><![CDATA[AT&T to enable HSUPA on Atrix 4G, Inspire 4G in April]]></title>
<link>http://www.haaze.com/story.php?title=att-to-enable-hsupa-on-atrix-4g-inspire-4g-in-april</link>
<comments>http://www.haaze.com/story.php?title=att-to-enable-hsupa-on-atrix-4g-inspire-4g-in-april</comments>
<pubDate>Fri, 25 Mar 2011 07:10:25 +0000</pubDate>
<dc:creator>chrmartsmh</dc:creator>
<category>Technology</category>
<guid>http://www.haaze.com/story.php?title=att-to-enable-hsupa-on-atrix-4g-inspire-4g-in-april</guid>
<description><![CDATA[Motorola Atrix 4G(Credit:Bonnie Cha/CNET)CNET has confirmed with AT&amp;T that it will enable the HSUPA radios on the Motorola Atrix 4G and HTC Inspire 4G via a software update in April.HSUPA, which stands for High-Speed Uplink Packet Access, is the protocol that enables faster upload speeds (up to 5.76Mbps) on your mobile phone. However, it recently came to light that the technology was disabled on the Atrix 4G and Inspire 4G, crippling the smartphones with slow-as-molasses upload speeds. The fact that these radios were not turned on was not disclosed to customers who bought the Atrix and Inspire, prompting calls to the Better Business Bureau, online petitions, and multiple forum threads. AT&amp;T couldn't provide us with a more specific time frame, but nevertheless, it's good to know that a fix is on the way. In addition, the upcoming Samsung Infuse 4Gs will ship with the HSUPA radio already turned on, so you should see faster upload speeds right out of the box, though the carrier cautions that other factors like location, time, and network capacity can affect data speeds. Thanks to Zack Nebbaki of DroidMatters.com for the tip!<br/><br/>0 Vote(s) ]]></description>
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<title><![CDATA[Retroficiency app sizes up building energy]]></title>
<link>http://www.haaze.com/story.php?title=retroficiency-app-sizes-up-building-energy</link>
<comments>http://www.haaze.com/story.php?title=retroficiency-app-sizes-up-building-energy</comments>
<pubDate>Wed, 09 Mar 2011 08:10:58 +0000</pubDate>
<dc:creator>chrmartsmh</dc:creator>
<category>Eco</category>
<guid>http://www.haaze.com/story.php?title=retroficiency-app-sizes-up-building-energy</guid>
<description><![CDATA[Retroficiency&amp;39's Web application is designed so energy auditors or building managers can get a quick idea of energy use and evaluate efficiency projects.(Credit:Retroficiency)Start-up Retroficiency today officially launched its service for streamlining efficiency projects in commercial buildings and said it has raised a seed round of funding. The Boston-based company said it has raised $800,000 from local angel investors and World Energy, which operates online auctions for bidding on energy supply contracts.Retroficiency's Web-based application is designed to quickly create a picture of a commercial building's energy profile and potential efficiency upgrades. It can be used by energy auditors to speed up creation of their reports or by buildings' facility managers to prioritize projects.Many building owners or occupants are interested in improving efficiency, but the manual process of sending out an energy services professional can be time-consuming, said CEO and founder Bennett Fisher. With the application, users fill out a survey with basic information, such as square footage, occupancy, and year built. Drawing on a database of existing buildings, it can infer more specifics, such as the type of lighting used and estimated electricity and gas usage. People can later update the profile with more specifics.&quot;There's a huge bottleneck of finding efficiency opportunities and going after this. New York City wants to audit 20,000 buildings. How are they going to do this with a guy walking around with a clipboard counting lightbulbs&quot; said Bennett. So far, Retroficiency has signed one customer--commercial building manager Jones Lang LaSalle--for its service and is in trials with a handful of others. In the commercial building efficiency area, there are dozens of large and small companies seeking to find a niche for their goods and services, in part because there's a lot of potential to save money and lighten buildings' environmental footprint. Bennett said he has found that its &quot;identification and qualification platform&quot; competes largely with manual processes and spreadsheets.<br/><br/>0 Vote(s) ]]></description>
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<title><![CDATA[Entrepreneur Corner: Board control and talent retention]]></title>
<link>http://www.haaze.com/story.php?title=entrepreneur-corner-board-control-and-talent-retention</link>
<comments>http://www.haaze.com/story.php?title=entrepreneur-corner-board-control-and-talent-retention</comments>
<pubDate>Mon, 30 Nov -001 00:00:00 +0000</pubDate>
<dc:creator>chrmartsmh</dc:creator>
<category>Latest News</category>
<guid>http://www.haaze.com/story.php?title=entrepreneur-corner-board-control-and-talent-retention</guid>
<description><![CDATA[Here&amp;'s the latest from VentureBeat&amp;'s Entrepreneur Corner.Demystifying the VC term sheet: Board control a4&quot; The issue of control of a company&amp;'s board is a common one after a round of Series A financing. Attorney Scott Edward Walker looks at ways you can retain in charge of your company a4&quot; or at least be on equal footing with your investor.The time has come to kill performance reviews a4&quot; Annual reviews are a pain a4&quot; for both managers and the people who receive them. David Stein, co-CEO of Rypple, offers an alternative idea that he says is more constructive and more effective.9 emerging minitrends to watch a4&quot; While the rest of the world looks for the next gigantic idea, there are plenty of smaller, but potentially immensely profitable trends that are being ignored. Author John Vanston looks at nine that are accessible to a wide variety of business sizes.Want to hang onto your best talent Try the unexpected a4&quot; The problem with things like annual bonuses is employees come to expect them a4&quot; and if they&amp;'re smaller than planned, morale sinks. Tony Hartl, founder of Planet Tan, argues that unexpected moments of reward and celebration have a significantly greater impact.Book review: The Breakthrough Company by Keith R. McFarland a4&quot; Growth is something to strive for in your startup, but when that growth comes to fast it can ruin some companies. Javier Rojas, managing director for Kennet Partners, examines the big takeaways and practical applications of author Keith McFarland&amp;'s &amp;''The Breakthrough Company,&amp;'' which focuses on the issue.Next Story: Week in review: 4chan founder says Zuckerberg is &amp;''wrong&amp;'' Previous Story: Gawker peeks into the war room of the hackers at AnonymousPrintEmailTwitterFacebookGoogle BuzzLinkedIn      DiggStumbleUponRedditDeliciousGoogleMore&amp;8230'          Tags: entrepreneur corner          Tags: entrepreneur cornerChris Morris is editor of the Entrepreneur Corner on VentureBeat, helping start-up business owners launch and grow their companies. He previously worked at Yahoo! Finance, where he was managing editor, and as director of content development at CNNMoney.com. He is also a widely respected journalist in the video game and technology fields, whose work has appeared in Variety, CNBC.com, AOL and Forbes.com. Follow him on Twitter at @MorrisatLarge Have news to share Launching a startup Email: tips@venturebeat.comVentureBeat has new weekly email newsletters.  Stay on top of the news, and don't miss a beat.<br/><br/>0 Vote(s) ]]></description>
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